The NASHA Technology
The HA in NASHA™ gel is obtained through bacterial fermentation using 100% non-animal ingredients.
A specific type of bacteria is used because of its ability to produce a high yield of HA. The HA is then purified and subjected to stabilization with only minimal modification ( ~ 1%), and a high degree of natural entanglements to create a long-lasting, biocompatible gel network. The patented technology behind NASHA is unique and should not be confused with other manufacturing process of HA gels resulting in highly cross-linked materials
The manufacturing of NASHA gel products is based on HA, a uniform, unbranched linear polysaccharide with the same chemical structure in all species and tissues. The identical structure of HA in all species makes this polysaccharide an ideal substance for use as a biomaterial in health products and medicine. HA can bind extensive amounts of water and is an important component of the extracellular space in the maintenance of the proper structure and function of tissue by creating volume, lubricating tissues, participating in normal cell functionalities.
The purity of the HA preparations is of the outmost importance for the safe use of HA products in humans. Impurities, especially protein and endotoxin origin from raw material may affect the biocompatibility as impurities may cause severe adverse reactions in the human body. The HA, and other components used for manufacturing NASHA gels are always tested for the presence of impurities, using sensitive and accurate methods, which ensures a high quality and impurity levels well below Pharmacopeia threshold levels.
The cornerstones of the NASHA technology are:
- Use pure HA of non-animal origin. The HA is manufactured through a biotechnology process using cultured bacteria and subjected to comprehensive purification steps to obtain a highly pure and consistent material.
- Stabilization of the HA raw material. A minimal modification (~ 1 %) is introduced to the HA molecule, and a high degree of natural entanglements is preserved to obtain the desired physical form and to increase its residence time in the body.